Photo by Ryan Coleman
Hotels in Sikeston
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Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1005)
9.6/10
Exceptional
(1005)
The price is $90
$90
$102 total
includes taxes & fees
Dec 24 - Dec 25
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (720)
8.4/10
Very Good
(720)
The price is $55
$55
$63 total
includes taxes & fees
Dec 21 - Dec 22
Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1001)
9.0/10
Wonderful
(1001)
The price is $70
$70
$79 total
includes taxes & fees
Dec 24 - Dec 25
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1003)
9.4/10
Exceptional
(1003)
The price is $90
$90
$103 total
includes taxes & fees
Dec 24 - Dec 25
Best Western Plus Sikeston
Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1003)
8.4/10
Very Good
(1003)
The price is $70
$70
$79 total
includes taxes & fees
Dec 24 - Dec 25
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
9.4/10
Exceptional
(1000)
The price is $95
$95
$107 total
includes taxes & fees
Dec 26 - Dec 27
Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1001)
9.4/10
Exceptional
(1001)
The price is $75
$75
$86 total
includes taxes & fees
Dec 24 - Dec 25
Courtyard by Marriott Cape Girardeau Downtown
Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (468)
9.6/10
Exceptional
(468)
The price is $116
$116
$131 total
includes taxes & fees
Dec 29 - Dec 30
Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (141)
9.4/10
Exceptional
(141)
The price is $88
$88
$99 total
includes taxes & fees
Dec 28 - Dec 29
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
8.8 out of 10, Excellent, (672)
8.8/10
Excellent
(672)
The price is $84
$84
$91 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
9.4/10
Exceptional
(1000)
The price is $90
$90
$102 total
includes taxes & fees
Dec 24 - Dec 25
Hampton Inn By Hilton Dexter
Hampton Inn By Hilton Dexter
2.5 star property
Dexter
10.0 out of 10, Exceptional, (2)
10/10
Exceptional
(2)
The price is $100
$100
$113 total
includes taxes & fees
Dec 28 - Dec 29
Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1001)
9.0/10
Wonderful
(1001)
The price is $70
$70
$79 total
includes taxes & fees
Dec 24 - Dec 25
Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1003)
9.6/10
Exceptional
(1003)
The price is $83
$83
$88 total
includes taxes & fees
Dec 21 - Dec 22
Super 8 by Wyndham Sikeston/Miner Area
Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
6.6 out of 10, (566)
6.6/10
(566)
The price is $59
$59
$68 total
includes taxes & fees
Dec 21 - Dec 22
Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (443)
8.6/10
Excellent
(443)
The price is $93
$93
$105 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Hampton Inn Cape Girardeau I 55 East
Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (785)
9.6/10
Exceptional
(785)
The price is $102
$102
$115 total
includes taxes & fees
Dec 26 - Dec 27
Travelodge by Wyndham Dexter
Travelodge by Wyndham Dexter
2.0 star property
Dexter
7.6 out of 10, Good, (386)
7.6/10
Good
(386)
The price is $74
$74
$83 total
includes taxes & fees
Dec 21 - Dec 22
The Riverview
The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (474)
9.4/10
Exceptional
(474)
The price is $96
$96
$109 total
includes taxes & fees
Dec 22 - Dec 23
Quality Inn Charleston - Sikeston
Quality Inn Charleston - Sikeston
2.5 star property
Charleston
6.8 out of 10, (406)
6.8/10
(406)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Check out pet-friendly hotels in Sikeston
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1005)
9.6/10
Exceptional
(1005)
The price is $90
$90
$102 total
includes taxes & fees
Dec 24 - Dec 25
9.4 out of 10, Exceptional, (1003)
9.4/10
Exceptional
(1003)
The price is $90
$90
$103 total
includes taxes & fees
Dec 24 - Dec 25
8.4 out of 10, Very Good, (1003)
8.4/10
Very Good
(1003)
The price is $70
$70
$79 total
includes taxes & fees
Dec 24 - Dec 25
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)2.5 star property
Sikeston
8.4 out of 10, Very Good, (720)
8.4/10
Very Good
(720)
The price is $55
$55
$63 total
includes taxes & fees
Dec 21 - Dec 22
Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical Center2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1001)
9.0/10
Wonderful
(1001)
The price is $70
$70
$79 total
includes taxes & fees
Dec 24 - Dec 25
9.4 out of 10, Exceptional, (1000)
9.4/10
Exceptional
(1000)
The price is $90
$90
$102 total
includes taxes & fees
Dec 24 - Dec 25
9.4 out of 10, Exceptional, (1001)
9.4/10
Exceptional
(1001)
The price is $75
$75
$86 total
includes taxes & fees
Dec 24 - Dec 25
Super 8 by Wyndham Sikeston/Miner Area
Super 8 by Wyndham Sikeston/Miner Area2.0 star property
Sikeston
6.6 out of 10, (566)
6.6/10
(566)
The price is $59
$59
$68 total
includes taxes & fees
Dec 21 - Dec 22
9.0 out of 10, Wonderful, (447)
9.0/10
Wonderful
(447)
The price is $98
$98
$110 total
includes taxes & fees
Dec 28 - Dec 29
7.6 out of 10, Good, (386)
7.6/10
Good
(386)
The price is $74
$74
$83 total
includes taxes & fees
Dec 21 - Dec 22
You may also like hotels with pools in Sikeston
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1005)
9.6/10
Exceptional
(1005)
The price is $90
$90
$102 total
includes taxes & fees
Dec 24 - Dec 25
9.4 out of 10, Exceptional, (1003)
9.4/10
Exceptional
(1003)
The price is $90
$90
$103 total
includes taxes & fees
Dec 24 - Dec 25
8.4 out of 10, Very Good, (1003)
8.4/10
Very Good
(1003)
The price is $70
$70
$79 total
includes taxes & fees
Dec 24 - Dec 25
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
9.4/10
Exceptional
(1000)
The price is $95
$95
$107 total
includes taxes & fees
Dec 26 - Dec 27
9.4 out of 10, Exceptional, (1000)
9.4/10
Exceptional
(1000)
The price is $90
$90
$102 total
includes taxes & fees
Dec 24 - Dec 25
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau3.0 star property
Jackson
8.8 out of 10, Excellent, (672)
8.8/10
Excellent
(672)
The price is $84
$84
$91 total
includes taxes & fees
Jan 7 - Jan 8, 2026
9.4 out of 10, Exceptional, (1001)
9.4/10
Exceptional
(1001)
The price is $75
$75
$86 total
includes taxes & fees
Dec 24 - Dec 25
Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape Girardeau2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (141)
9.4/10
Exceptional
(141)
The price is $88
$88
$99 total
includes taxes & fees
Dec 28 - Dec 29
9.6 out of 10, Exceptional, (102)
9.6/10
Exceptional
(102)
The price is $89
$89
$102 total
includes taxes & fees
Jan 12 - Jan 13, 2026
9.0 out of 10, Wonderful, (447)
9.0/10
Wonderful
(447)
The price is $98
$98
$110 total
includes taxes & fees
Dec 28 - Dec 29
You can also stay at family-friendly hotels in Sikeston
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1005)
9.6/10
Exceptional
(1005)
The price is $90
$90
$102 total
includes taxes & fees
Dec 24 - Dec 25
9.4 out of 10, Exceptional, (1003)
9.4/10
Exceptional
(1003)
The price is $90
$90
$103 total
includes taxes & fees
Dec 24 - Dec 25
Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical Center2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1001)
9.0/10
Wonderful
(1001)
The price is $70
$70
$79 total
includes taxes & fees
Dec 24 - Dec 25
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau3.0 star property
Jackson
8.8 out of 10, Excellent, (672)
8.8/10
Excellent
(672)
The price is $84
$84
$91 total
includes taxes & fees
Jan 7 - Jan 8, 2026
9.4 out of 10, Exceptional, (1001)
9.4/10
Exceptional
(1001)
The price is $75
$75
$86 total
includes taxes & fees
Dec 24 - Dec 25
Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape Girardeau2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (141)
9.4/10
Exceptional
(141)
The price is $88
$88
$99 total
includes taxes & fees
Dec 28 - Dec 29
10.0 out of 10, Exceptional, (2)
10/10
Exceptional
(2)
The price is $100
$100
$113 total
includes taxes & fees
Dec 28 - Dec 29
Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MO2.0 star property
Charleston
6.6 out of 10, (612)
6.6/10
(612)
The price is $62
$62
$69 total
includes taxes & fees
Dec 21 - Dec 22
6.8 out of 10, (406)
6.8/10
(406)
Candlewood Suites Cape Girardeau by IHG
Candlewood Suites Cape Girardeau by IHG2.5 star property
Cape Girardeau
8.2 out of 10, Very Good, (882)
8.2/10
Very Good
(882)
The price is $77
$77
$92 total
includes taxes & fees
Jan 19 - Jan 20, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Sikeston
Pet friendly
Family friendly
When is the best time to visit Sikeston?
When is the best time to visit Sikeston?Our prices for hotels in Sikeston are cheapest in December
When is the best time to visit Sikeston?
When is the best time to visit Sikeston?
Our prices for hotels in Sikeston are cheapest in December
Price trends for hotels in Sikeston
Pricing is based on two traveler single night rates
Currently viewing crowd sizes and weather for December.
Typical weather for Sikeston
December
Low crowds
High 9°C / low 2°C. Partly sunny.
View properties in December 9°
December, Low crowds, average high temperature 9 degrees Celsius, average low temperature 2 degrees Celsius. Partly sunny.
2°
6°
January, Low crowds, average high temperature 6 degrees Celsius, average low temperature -1 degrees Celsius. Partly sunny.
-1°
8°
February, Low crowds, average high temperature 8 degrees Celsius, average low temperature 0 degrees Celsius. Partly sunny.
0°
14°
March, Moderate crowds, average high temperature 14 degrees Celsius, average low temperature 5 degrees Celsius. Partly sunny.
5°
20°
April, High crowds, average high temperature 20 degrees Celsius, average low temperature 10 degrees Celsius. Sunny most days.
10°
25°
May, Moderate crowds, average high temperature 25 degrees Celsius, average low temperature 16 degrees Celsius. Sunny most days.
16°
30°
June, High crowds, average high temperature 30 degrees Celsius, average low temperature 20 degrees Celsius. Sunny most days.
20°
32°
July, High crowds, average high temperature 32 degrees Celsius, average low temperature 22 degrees Celsius. Sunny most days.
22°
31°
August, High crowds, average high temperature 31 degrees Celsius, average low temperature 21 degrees Celsius. Sunny most days.
21°
28°
September, Moderate crowds, average high temperature 28 degrees Celsius, average low temperature 17 degrees Celsius. Sunny most days.
17°
21°
October, Moderate crowds, average high temperature 21 degrees Celsius, average low temperature 11 degrees Celsius. Sunny most days.
11°
14°
November, Low crowds, average high temperature 14 degrees Celsius, average low temperature 5 degrees Celsius. Partly sunny.
5°
Monthly weather averages (˚C)
Top landmarks in Sikeston
Sikeston and related destinations
Catch a hot roll in mid-air at Lambert's Cafe, where servers hurl fresh bread across the dining room with remarkable accuracy. The historic downtown reveals a slice of small-town Americana, while the Sikeston Depot Museum chronicles the railroad heritage that put this place on the map. Central Park offers a leafy respite after exploring Front Street Studio & Art Gallery's local artwork. The City of Miner Convention Center hosts events that draw visitors from across the region. Positioned at the crossroads of major highways, this makes an ideal stopover between larger destinations, though locals insist you'll find reasons to linger beyond the flying carbs that made the town famous.
Photo by Ryan Coleman
Open Photo by Ryan Coleman
Check out reviews of Sikeston hotels guests love
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
10/10 Excellent
"Very clean premises, easy check-in, quiet, good breakfast and Wendy, the receptionist was the BEST ever in providing professional, quality and attentive customer service with a smile and warm welcome!"
Candlewood Suites Cape Girardeau by IHG
10/10 Excellent
"Room was clean and spacious."
The Riverview
10/10 Excellent
"The room was clean and the mattress was extremely comfortable "
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
10/10 Excellent
"It was amazing check in to check out"
Drury Inn & Suites Jackson MO
10/10 Excellent
"Yes"
Drury Inn & Suites Cape Girardeau
10/10 Excellent
"The staff was all friendly clean rooms and really enjoyed our stay"
Drury Inn & Suites Sikeston, MO
10/10 Excellent
"Clean room, friendly staff"
Super 8 by Wyndham Sikeston/Miner Area
10/10 Excellent
" Clean rooms , quiet , excellent hotel staff."
Hampton Inn Sikeston
10/10 Excellent
"Yes"
Frequently asked questions
What accommodations do travelers recommend in Sikeston?
Pear Tree Inn Sikeston, Fairfield Inn & Suites by Marriott Sikeston and Drury Inn & Suites Sikeston, MO are all accommodations that are popular with guests.
Can I book a refundable accommodation in Sikeston?
If you're looking for the flexibility to change your travel plans to Sikeston, most properties provide refundable* rates you can book. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in Sikeston if I want a cheap accommodation?
Two inexpensive options worth considering are Hampton Inn Sikeston and Days Inn and Suites by Wyndham Sikeston.
What will the weather in Sikeston be like during my vacation?
The warmest months in Sikeston are usually July and August with an average temp of 77°F. January and February are the chilliest months when the average temp is 41°F. The rainiest months are April and March.
Why should I book my Sikeston hotel with Hotels.com?
There are plenty of reasons to book your Sikeston travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.