Hotels in Irene

your current months are January, 2025 and February, 2025.
January 2025
February 2025

Find and book your perfect stay

Earn rewards on every night you stay
Save more with Member Prices
Free cancellation options if plans change

Where to stay in Irene?

Holiday Inn Express & Suites Yankton, an IHG Hotel
Exterior

Holiday Inn Express & Suites Yankton, an IHG Hotel

2.5 star property
9.2 out of 10, Wonderful, (370)
The price is $105
$116 total
includes taxes & fees
Dec 28 - Dec 29
Holiday Inn Express & Suites Yankton, an IHG Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Irene

Irene is well-known for its attractions such as Lewis and Clark Recreation Area and Lewis and Clark Lake.

See all hotels in Irene

Frequently asked questions

Can I book refundable hotels in Irene?
If you’re looking for the flexibility to change your plans to Irene, most accommodations provide refundable* bookable rates. You can see these properties by searching our site and using the “fully refundable” filter to narrow down the results.
What will the weather in Irene be like during my vacation?
July and August are typically the warmest months in Irene when the average temp is 72°F. January and February are the coldest months when the average temperature is 26°F. June and May are the months with the most rain.
Why should I book my Irene accommodation with Hotels.com?
There are lots of reasons to book your Irene trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.