Hotels in Cayo Guillermo

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Tonight
Apr 16 - Apr 17
Tomorrow
Apr 17 - Apr 18
This weekend
Apr 18 - Apr 20
Next weekend
Apr 25 - Apr 27

Where to stay in Cayo Guillermo?

Top landmarks in Cayo Guillermo

Cayo Guillermo Beach

Cayo Guillermo Beach

If being by the water is a major draw, Cayo Guillermo Beach is a spot you might want to check out, located 2.1 mi (3.4 km) from central Cayo Guillermo.

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Cayo Guillermo Beach

Cayo Guillermo Marina

Cayo Guillermo Marina is worth a visit, located 2.6 mi (4.2 km) from central Cayo Guillermo.

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Cayo Guillermo Marina

Learn more about Cayo Guillermo

The region around Cayo Guillermo is home to attractions such as Cayo Guillermo Beach and Cayo Guillermo Marina.

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Frequently asked questions

What accommodations do travelers recommend in Cayo Guillermo?
Guests like Hotel Grand Muthu Cayo Guillermo, Iberostar Daiquirí - All inclusive and Club Cayo Guillermo - All Inclusive.
Where can I get free parking with my stay in Cayo Guillermo?
Iberostar Daiquirí - All inclusive offers the perk of free parking.
Can I book a refundable accommodation in Cayo Guillermo?
If you want the flexibility to change your travel plans to Cayo Guillermo, most accommodations provide refundable* bookable rates. You can find these properties by searching our site and using the “fully refundable” filter to narrow the results down.
Where should I stay in Cayo Guillermo if I want a cheap accommodation?
An inexpensive option worth considering is Villa Gregorio.
What will the weather in Cayo Guillermo be like during my vacation?
With an average temperature of 76°F during the coldest months, Cayo Guillermo is a great place to visit any time of year.
Why should I book my Cayo Guillermo accommodation with Hotels.com?
There are plenty of reasons to book your Cayo Guillermo travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.