Hotels in Southeast Missouri

Free cancellation options if plans change
Earn rewards on every night you stay
Save more with Member Prices

Check prices for these dates

Tonight
Apr 24 - Apr 25
Tomorrow
Apr 25 - Apr 26
This weekend
Apr 25 - Apr 27
Next weekend
May 2 - May 4

Where to stay in Southeast Missouri?

Arcadia Academy
Comfort Penthouse, Multiple Beds | Living area

Arcadia Academy

3.0 star property
10.0 out of 10, Exceptional, (1)
The price is $112
$122 total
includes taxes & fees
Apr 25 - Apr 26
Arcadia Academy
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southeast Missouri, MO

Showing deals for:May 2 - May 4

Image gallery for Fairfield Inn & Suites by Marriott Cape Girardeau

Lobby

Fairfield Inn & Suites by Marriott Cape Girardeau

2.5 star property
Cape Girardeau
9.4/10Exceptional (101 reviews)
15% off
Price is $131
per night
$295 total
includes taxes & fees
Fairfield Inn & Suites by Marriott Cape Girardeau

Top landmarks in Southeast Missouri

Taum Sauk Mountain in located in the St.Francis mountain range of south/central Missouri. It's also the highest point in Missouri. My kids are standing at the spot where the actual marker sign in

Elephant Rocks State Park

Elephant Rocks State Park is 5.3 mi (8.5 km) from central Ironton, why not stop by during your stay.

See properties in Elephant Rocks State Park
Elephant Rocks State Park

Learn more about Southeast Missouri

Southeast Missouri is well-known for its wineries and riverfront while attractions include Sam A. Baker State Park and K Bridge Recreation Area. This family-friendly city has something for everyone including its university life, restaurants, and sights like Lake Wappapello State Park and Clearwater Lake.

See all hotels in Southeast Missouri

Frequently asked questions

Can I book a refundable accommodation in Southeast Missouri?
If you need the flexibility to change your travel plans to Southeast Missouri, most hotels provide refundable* rates you can book. You can see these accommodations by searching our site and using the “fully refundable” filter to narrow the results down.
Where can I stay in Southeast Missouri if I want a vacation home instead of a traditional hotel?
If you want a good alternative to a hotel, look over our selection of 129 vacation homes. In addition, there are 46 apartments and 7 condos.
Why should I book my Southeast Missouri accommodation with Hotels.com?
There are plenty of reasons to book your Southeast Missouri travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.