Hotels in Eastern Panama

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Tonight
Mar 21 - Mar 22
Tomorrow
Mar 22 - Mar 23
This weekend
Mar 21 - Mar 23
Next weekend
Mar 28 - Mar 30

Where to stay in Eastern Panama?

Cocoloco - Catamaran Lagoon 52F SAN BLAS
Exterior

Cocoloco - Catamaran Lagoon 52F SAN BLAS

3.0 star property
The price is $1,808
$1,989 total
includes taxes & fees
Apr 4 - Apr 5
Cocoloco - Catamaran Lagoon 52F SAN BLAS
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in Eastern Panama

Museum of the Kuna Nation

Museum of the Kuna Nation is 0.3 mi (0.5 km) from central Masargantupo, why not stop by during your stay. If you want to experience more of the culture Masargantupo has to offer, head to Cayos Holandeses.

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Museum of the Kuna Nation

Learn more about Eastern Panama

Eastern Panama is well-known for its attractions such as Cayos Holandeses and Chagres National Park. The city has something for everyone including sights like Darien National Park and Portobelo National Park within a tropical setting.

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Frequently asked questions

Can I book refundable accommodations in Eastern Panama?
If you want the flexibility to change your plans to Eastern Panama, most hotels provide refundable* rates you can book. You can find these properties by searching our site and using the “fully refundable” filter to narrow down the results.
Where can I stay in Eastern Panama if I want a vacation rental instead of a traditional hotel?
If you’re looking for a good alternative to a hotel, look over our selection of 14 vacation homes. You can also book one of the 16 cabins for your stay.
Why should I book my Eastern Panama hotel with Hotels.com?
There are plenty of reasons to book your Eastern Panama travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.