Hotels in Florida Keys

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Check prices for these dates

Tonight
Mar 30 - Mar 31
Tomorrow
Mar 31 - Apr 1
Next weekend
Apr 4 - Apr 6
In two weeks
Apr 11 - Apr 13

Where to stay in Florida Keys?

Looe Key Reef Resort
Boating

Looe Key Reef Resort

2.5 star property
7.4 out of 10, Good, (1070)
The price is $172
$194 total
includes taxes & fees
Apr 23 - Apr 24
Looe Key Reef Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Florida Keys

Showing deals for:Apr 11 - Apr 13

Image gallery for Southernmost Beach Resort and Guesthouses

3 outdoor pools, pool umbrellas, sun loungers
VIP Access

Southernmost Beach Resort and Guesthouses

4.0 star property
Key West
8.6/10Excellent (2,603 reviews)
15% off
Price is $662
per night
$1,625 total
includes taxes & fees
Southernmost Beach Resort and Guesthouses

Top neighborhoods in Florida Keys

Key West Historic District

Old Town Key West

Old Town, the historic heart of Key West, boasts a central business district and numerous tourist attractions. Explore the Key West Aquarium, Ernest Hemingway House, Mallory Square, and more in this vibrant area.

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Old Town Key West

Top landmarks in Florida Keys

Duval Street featuring signage

Duval Street

If you want to give your credit card some exercise, head out to Duval Street, a popular place for shoppers in Key West Historic District. Splash some more cash at We Cycle Key West and Mallory Dock.

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Duval Street

Learn more about Florida Keys

Florida Keys is admired for its seaside and live music while top attractions include Everglades National Park and Duval Street. This beachside city has something for everyone including its entertainment, bars, and sights like Vaca Key and Sombrero Beach.

See all hotels in Florida Keys
Higgs Beach showing a sandy beach and tropical scenes as well as a large group of people

Frequently asked questions

Can I book a refundable hotel in Florida Keys?
If you need the flexibility to change your plans to Florida Keys, most properties provide refundable* rates you can book. You can find these accommodations by searching our site and using the “fully refundable” filter to narrow the results down.
Where can I stay in Florida Keys if I want a vacation home instead of a traditional hotel?
If you’re looking for a good alternative to a hotel, browse our selection of 4186 vacation homes. In addition, there are 391 apartments and 1237 condos.
Why should I book my Florida Keys hotel through Hotels.com?
There are lots of reasons to book your Florida Keys trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.