Hotels in South Carolina Lowcountry

your current months are January, 2025 and February, 2025.
January 2025
February 2025

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Where to stay in South Carolina Lowcountry?

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top neighborhoods in South Carolina Lowcountry

Top landmarks in South Carolina Lowcountry

Learn more about South Carolina Lowcountry

South Carolina Lowcountry is applauded for its cultural attractions such as Penn Center and Highway 21 Drive-In Theater.

Hilton Head featuring heritage architecture
Photo by Hilton Head Island Visitor & Convention Bureau
Open Photo by Hilton Head Island Visitor & Convention Bureau

Frequently asked questions

Can I book refundable hotels in South Carolina Lowcountry?
If you want the flexibility to change your travel plans to South Carolina Lowcountry, most hotels provide refundable* bookable rates. You can find these properties by searching our site and using the “fully refundable” filter to narrow down the results.
Where can I stay in South Carolina Lowcountry if I want a vacation home instead of a hotel?
If you want to find a good alternative to a hotel, review our selection of 4188 vacation homes. In addition, there are 225 apartments and 3043 condos.
Why should I book my South Carolina Lowcountry accommodation with Hotels.com?
There are lots of reasons to book your South Carolina Lowcountry trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.