Hotels in Upstate South Carolina

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Apr 12 - Apr 13
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Apr 18 - Apr 20
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Apr 25 - Apr 27

Where to stay in Upstate South Carolina?

Hotel Hartness
Interior entrance

Hotel Hartness

4.0 star property
9.8 out of 10, Exceptional, (492)
The price is $169
$220 total
includes taxes & fees
Apr 13 - Apr 14
Hotel Hartness
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Upstate South Carolina, SC

Showing deals for:Apr 25 - Apr 27

Image gallery for Liberty Hall Bed and Breakfast

Front of property
VIP Access

Liberty Hall Bed and Breakfast

4.0 star property
Pendleton
10/10Exceptional (60 reviews)
11% off
Price is $200
per night
$543 total
includes taxes & fees
Liberty Hall Bed and Breakfast

Top neighborhoods in Upstate South Carolina

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Green Avenue

The Green Avenue neighborhood offers attractions such as Falls Park on the Reedy and Greenville Zoo.

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Green Avenue

Top landmarks in Upstate South Carolina

Clemson University

Clemson University

Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.

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Clemson University

Learn more about Upstate South Carolina

Upstate South Carolina is well-known for its university life and sports, featuring attractions such as Discovery Island Water Park and Frankie's Fun Park. This family-friendly city has something for everyone including its live music, restaurants, and sights like Conestee Nature Preserve and Heritage Park.

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Greenville - Spartanburg showing a sunset, tranquil scenes and mountains
Photo by South Carolina Department of Parks, Recreation & Tourism
Open Photo by South Carolina Department of Parks, Recreation & Tourism

Frequently asked questions

Can I book refundable accommodations in Upstate South Carolina?
If you’re looking for the flexibility to change your plans to Upstate South Carolina, most accommodations provide refundable* rates you can book. You can see these properties by searching our site and using the “fully refundable” filter to narrow the results down.
Where can I stay in Upstate South Carolina if I want a vacation rental instead of a hotel?
If you want to find a good alternative to a hotel, browse our selection of 1070 vacation homes. In addition, there are 113 apartments and 89 condos.
Why should I book my Upstate South Carolina hotel through Hotels.com?
There are lots of reasons to book your Upstate South Carolina trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.